Start Your Pro-Age Skincare System with Biotulin's Bestselling Pro-Age Smoothing Serum Concentrate

Inspired by gold-standard aesthetic wrinkle-smoothing treatments

Clinically measured to visibly reduce the appearance of wrinkle depth:
−6.8% wrinkle depth in 1 hour
−10.4% after 28 days with regular use

Barrier-friendly · Non-Irritating · 80% Plant-Based

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Inspired by gold-standard aesthetic wrinkle-smoothing treatments

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As seen on

High-performance pro-age skincare, inspired by aesthetic care

A new standard in everyday wrinkle-smoothing care

BESTSELLERS

THE BIOTULIN EFFECT FORMULA SCIENCE

Clinically Measured Pro-Age Skincare, Inspired by In-Clinic Aesthetic Treatments.

Developed through advanced German skincare research, the Biotulin Effect is a pro-age formulation approach designed to deliver visible results and progressively improve skin quality with consistent use.

Every formula is built around 4 principles:

SMART PERFORMANCE

Inspired by In-Clinic Aesthetic Treatments

PROGRESSIVE SKIN REFINEMENT

BARRIER RESPECTING DELIVERY

The Hidden Cause of Expression Lines

The problem: micro-contractions

Every smile, frown and squint is a small contraction of the facial muscles. Every day, your skin responds with countless micro-contractions. Repeated over the years, they fold the skin in the same places, and fine lines and wrinkles form on the forehead, between the brows and around the eyes.

The Biotulin solution: Spilanthol

The Biotulin Effect is powered by Spilanthol, a plant active from the Paracress flower (Acmella oleracea) that softens facial micro-contractions. Muscles relax without being paralyzed, so skin looks visibly smoother while your natural expressions stay intact.

DISCOVER THE SCIENCE

Supreme Skin Gel

The Biotulin Effect, in two actives: Spilanthol, a plant-derived active known for its relaxing effect on facial expressions, visibly softens the look of mimic wrinkles - the natural smoothing principle of in-clinic aesthetics, expressed in skincare.

Hyaluronic Acid works alongside it, binding moisture across multiple layers to replump and restore the look of bounce and elasticity. Together they form one system: smoothing where expression leaves its mark, hydration that holds it, for skin that looks smoother, fresher and more refined.

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BEFORE/AFTER

The Biotulin Effect Clinically Measured

Biotulin isn’t just a promise; it’s performance you can measure.

From the very first hour, it begins to smooth wrinkles with a visible –6.8% reduction in depth.

After 28 days of twice-daily use, that effect deepens to –10.4%; proving its power to transform skin over time.

These results aren’t based on opinions; they’re measured by dermatological instruments on real women, in real conditions. Instrumental test using PRIMOS on 30 women over 28 days. Real-time, 3D measurement of skin texture.

The Signature Pro Age System for Clinically Measured Smoothing & Lasting Hydration

One targeted pro-age daily care for your skin type. Two daily pro-age steps to complete the Biotulin Effect: Signature pro-age smoothing serum concentrate and matching 24H cream.

CHOOSE YOUR SKIN TYPE

3-Week Everyday Treatment

Pro-Age Smoothing & Hydration System Starter Set

Normal to Combination Skin

89,00 €118,00 € 4.5

6-Week Everyday Treatment

Pro-Age Smoothing & Hydration Signature System Set

Normal to Combination Skin

109,00 €167,00 € 4.5

3-Week Everyday Treatment

Pro-Age Smoothing, Intense Hydration & Nourishing System Starter Set

Dry to Very Dry Skin

89,00 €118,00 € 4.5

6-Week Everyday Treatment

Pro-Age Smoothing, Intense Hydration & Nourishing Signature System Set

Dry to Very Dry Skin

109,00 €167,00 € 4.5

EXPLORE CATEGORIES

"A serum adored by VIPs that delivers visible smoothing in just 60 minutes."

"A non-invasive alternative to traditional anti-aging methods."

“This is THE glow booster with an instant effect”

"The perfect B*tox alternative"

“Smooths and firms the skin in just 60 minutes”

Your Biotulin Skin Routine

01. Cleanse

Begin your day by gently cleansing your face with B*Clean All-In-One Cleansing & Smoothing Micellar Water. Soak a cotton pad with the product and gently swipe it across your face and neck.